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5, 6 Furthermore, some women indicated that a physician’s advice played a key role in their decision whether to eat fish during pregnancy. 4 Recent surveys have demonstrated that, despite the FDA/EPA advisory indicating that up to 2 servings of fish is safe in pregnancy, many pregnant women consume little to no fish, thereby potentially depriving the fetus of necessary nutrients. For this reason, the FDA/EPA recommends limiting fish consumption to 2 servings (approximately 340 g or 12 oz of seafood) per week. Seafood can also contain organic mercury and other harmful toxins (eg, polychlorinated biphenyls ), which could be harmful to the growing fetus. 3 A woman can achieve this threshold by consuming 1 to 2 servings of seafood per week, dietary intake that is consistent with the current US Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) advisory. 1 To optimize pregnancy outcomes and fetal health, consensus guidelines have recommended that pregnant women consume at least 200 mg of DHA per day. 2 For these reasons, it is important for omega-3 fatty acids to be supplied to the fetus in adequate amounts throughout pregnancy. Animal studies have demonstrated that deprivation of omega-3 fatty acids during pregnancy is associated with visual and behavioral deficits that cannot be reversed with postnatal supplementation. It is likely that, during pregnancy, omega-3 requirements increase over normal to support fetal growth, particularly of the brain and eyes. 1 Fetal brain growth accelerates during the second half of pregnancy, and the rate of growth remains high during the first year of life with continued growth for the next several years. Both have been shown to have multiple beneficial effects, including improving childhood development when ingested during pregnancy. The most biologically active omega-3 fatty acids are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Fish and other seafood contain long-chain omega-3 polyunsaturated fatty acids (PUFA), which are essential nutrients.